Synthesis and antihyperlipidaemic activity of a new piperine derivative

Authors

  • Mungunnaran Damdindorj Graduate school, Mongolian University of Life Sciences, Ulaanbaatar, 17024, Mongolia
  • Gereltu Borjihan Institute of Mongolian Medicine Chemistry, Inner Mongolia University, 235 Da Xue West Road, Hohhot, 010020, P.R. China.
  • Odontuya Gendaram Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences, Ulaanbaatar, 13330, Mongolia.
  • Bayarmaa Bold Research and Innovation office, Mongolian University of Life Sciences, Ulaanbaatar, 17024, Mongolia. https://orcid.org/0000-0002-6797-821X

DOI:

https://doi.org/10.5564/mjc.v22i48.1782

Keywords:

Piperine, alkaloid, cholesterol, hyperlipidemia, amino acid, solubility

Abstract

Long pepper (Piper longum Linn.) is widely used as a medicinal substance in traditional Ayurvedic medicine. Its major alkaloid piperine is the main active constituent with various therapeutic activities and has low solubility in water. In this study, a soluble new derivative of a piperine alkaloid, named N-leucinylpiperamide was synthesized. The animal experiment showed that N-leucinylpiperamide has more hypolipidemic effects than commercially available simvastatin and piperine in modulating serum lipids in Wistar male rats. At the amount of 10 mg/kg bw, it significantly reduced TC (-52.4%), TG (-61.7%), and LDL-C (-27.8%), respectively, and increased HDL-C (+147.4%) in the serum of the high-lipid model group. Furthermore, the synthesized N-leucinylpiperamide had no noticeable cytotoxicity against HepG2 cell line in vitro. Thus, our study shows that N-leucinylpiperamide has an ability to improve serum lipid profile in hyperlipidemic model rats and could be a valuable promising agent for the preventing hyperlipidemia.

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Author Biography

Mungunnaran Damdindorj, Graduate school, Mongolian University of Life Sciences, Ulaanbaatar, 17024, Mongolia

  • Institute of Mongolian Medicine Chemistry, Inner Mongolia University, 235 Da Xue West Road,
    Hohhot, 010020, P.R. China
  • Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences, Ulaanbaatar, 13330, Mongolia

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Published

2021-12-29

How to Cite

Damdindorj, M., Borjihan, G., Gendaram, O., & Bold, B. (2021). Synthesis and antihyperlipidaemic activity of a new piperine derivative. Mongolian Journal of Chemistry, 22(48), 13–18. https://doi.org/10.5564/mjc.v22i48.1782

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