Chemical constituents of aerial parts of Thymus gobicus and their cholinesterase inhibitory activities

Authors

  • Odonbayar B Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan
  • T Murata Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan
  • N Matsumoto Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan
  • Batkhuu J School of Engineering and Applied Sciences, National University of Mongolia, POB-617, Ulaanbaatar-46A, 14201, Mongolia
  • K Sasaki Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan

DOI:

https://doi.org/10.5564/mjc.v17i43.740

Keywords:

Thymus gobicus, phenylpropanoid, monardic acid A, Nepetoidin B, lithospermic acid,

Abstract

From an acetone-water (3:2) extract of aerial parts of Thymus gobicus Czern. (31.1 g), compounds 1-8 were obtained using high-performance liquid chromatography. Based on spectroscopic data, the isolated compounds were identified as rosmarinic acid (1), monardic acid A (2), nepetoidin B (3), aromadendrin (4), apigenin (5), chrysoriol (6), apigenin 7-O-β-D-glucuronopyranoside (7), and apigenin 7-O-β-D-glucuronopyranoside methyl ester (8). Compound 2 was a (7R,8R)-diastereomer of lithospermic acid (2a). Although it was reported that the anti-allergic activity of lithospermic acid was higher than that of 2, the acetylcholine inhibitory activity of 2 was higher than that of lithospermic acid.

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Published

2017-02-03

How to Cite

B, O., Murata, T., Matsumoto, N., J, B., & Sasaki, K. (2017). Chemical constituents of aerial parts of Thymus gobicus and their cholinesterase inhibitory activities. Mongolian Journal of Chemistry, 17(43), 14–17. https://doi.org/10.5564/mjc.v17i43.740

Issue

Vol. 17 No. 43 (2016)

Section

Articles

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