Wound-healing activity of polyhexamethyleneguanidine hydrochloride hydrogel and extract of Bergenia crassifolia on thermal burn simulation

Authors

  • Sergey A. Stelmakh Baikal Institute of Nature Management, Siberan Branch, Russian Academy of Sciences, 6, Sakhyanova Street, Ulan-Ude 670043, Russia https://orcid.org/0000-0003-3392-5600
  • Oleg S. Ochirov Baikal Institute of Nature Management, Siberian Branch, Russian Academy of Sciences, 6, Sakhyanova Street, Ulan-Ude 670043, Russia
  • Maria N. Grigor’eva Baikal Institute of Nature Management, Siberian Branch, Russian Academy of Sciences, Sakhyanova Str., 6, Ulan-Ude 670043, Russia.
  • Anatoly A. Tykheev East Siberia State University of Technologies and Management 40V, Klyuchevskaya Str., 1, Ulan-Ude 670013, Russia
  • Svetlana N. Lebedeva East Siberia State University of Technologies and Management 40V, Klyuchevskaya Str., 1, Ulan-Ude 670013, Russia
  • Valeria O. Okladnikova Baikal Institute of Nature Management, Siberian Branch, Russian Academy of Sciences, Sakhyanova Str., 6, Ulan-Ude 670043, Russia.
  • Sesegma D. Zhamsaranova East Siberia State University of Technologies and Management 40V, Klyuchevskaya Str., 1, Ulan-Ude 670013, Russia.

DOI:

https://doi.org/10.5564/mjc.v23i49.2049

Keywords:

wound healing, hydrogel, extract, polyhexamethylene guanidine hydrochloride, toxicity

Abstract

The results of a study of the wound healing activity of a composition based on the hydrogel of polyhexamethylene guanidine hydrochloride and Bergenia crassifolia extract, under conditions of modeling thermal burns in laboratory animals (rats), are presented. It was found that the composition affects the change in the summary antioxidant and leukocyte activity towards the normalization of these indicators. Morphological analysis of the slices showed that, under the influence of a polyhexamethylene guanidine hydrogel composition and B.crassifolia extract, healing proceeds more intensively than in the control group and is manifested by a smaller thickness of the leukocyte-necrotic scab, accelerated epithelization, and complete closure of the skin defect.

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Published

2022-12-23

How to Cite

Stelmakh, S., Ochirov, O., Grigor’eva, M., Tykheev, A., Lebedeva, S., Okladnikova, V., & Zhamsaranova, S. (2022). Wound-healing activity of polyhexamethyleneguanidine hydrochloride hydrogel and extract of Bergenia crassifolia on thermal burn simulation. Mongolian Journal of Chemistry, 23(49), 51–62. https://doi.org/10.5564/mjc.v23i49.2049

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