The Impact of Hepatitis D Coinfection on the Hepatitis Flare during Chemotherapy for B-Cell Non-Hodgkin Lymphoma

Authors

  • Myagmarjav Budeebazar Liver Center, Ulaanbaatar, Mongolia
  • Anir Enkhbat Liver Center, Ulaanbaatar, Mongolia
  • Delgerbat Boldbaatar Liver Center, Ulaanbaatar, Mongolia
  • Khishigjargal Batsukh Center of Hematology and Bone Marrow, Transplantation, First Central Hospital of Mongolia
  • Altankhuu Murdoj Liver Center, Ulaanbaatar, Mongolia
  • Erdenetsogt Dungubat Department of Pathology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Dagvadorj Yagaanbuyant Liver Center, Ulaanbaatar, Mongolia
  • Naranjargal Dashdorj Liver Center, Ulaanbaatar, Mongolia
  • Davaadorj Duger Department of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongoli

DOI:

https://doi.org/10.24079/cajms.2020.03.003

Keywords:

anti-HDV, chemotherapy, hepatitis B virus, hepatitis flare, non-Hodgkin lymphoma

Abstract

Objectives: This study was conducted to determine the effect of Hepatitis B infection with or without D coinfection on the hepatitis flare associated with chemotherapy for B-Cell non-Hodgkin lymphoma. Methods: The hepatitis flare related to the chemotherapy for newly diagnosed B-Cell non-Hodgkin lymphoma was studied in HBV mono-infected and HBV and HDV coinfected patients between 2015 and 2018. Results: Nineteen HBsAg positive patients satisfied the inclusion criteria. In the group with the hepatitis flare, 14.3% were anti-HDV negative and 83.3% were anti-HDV positive (p<.006). Also, the hepatitis flare occurred in all patients where HDV-RNA was detected, while it had occurred in 60% of patients where HDV-RNA was not detected. Conclusion: The hepatitis flare related to chemotherapy occurred more frequently in B-Cell non-Hodgkin lymphoma patients coinfected with HBV and HDV without antiviral prophylaxis, especially when HDV-RNA was detected.

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Author Biography

Erdenetsogt Dungubat, Department of Pathology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

Department of Pathology, International University of Health and Welfare, Narita Campus, Japan,

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Published

2020-04-01

How to Cite

Budeebazar, M., Enkhbat, A., Boldbaatar, D., Batsukh, K., Murdoj, A., Dungubat, E., Yagaanbuyant, D., Dashdorj, N., & Duger, D. (2020). The Impact of Hepatitis D Coinfection on the Hepatitis Flare during Chemotherapy for B-Cell Non-Hodgkin Lymphoma. Central Asian Journal of Medical Sciences, 6(1), 347–356. https://doi.org/10.24079/cajms.2020.03.003

Issue

Vol. 6 No. 1 (2020)

Section

Articles

License

Copyright (c) 2020 Mongolian National University of Medical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.