Non-Ossifying Fibroma Mimicking Extra-Neural Metastasis in Pediatric Cerebral Anaplastic Ependymoma: A Case Report
DOI:
https://doi.org/10.24079/cajms.2024.04.005Keywords:
Fibroma, Ependymoma, Neoplasm metastasis, Positron-emission tomographyAbstract
Objective: This case report focuses on the differential diagnosis of non-ossifying fibroma and extra-neural metastasis in pediatric cerebral anaplastic ependymoma. Methods: Magnetic resonance imaging, computed tomography, positron emission tomography, and biopsy were performed. Results: An 11-year-old patient who had undergone surgical removal of an anaplastic ependymoma was referred for a positron emission tomography examination for follow-up. The positron emission tomography revealed a fluorodeoxyglucose-avid lesion in the left proximal tibia, raising suspicion of bone metastasis. Subsequently, a biopsy was performed, and the lesion was confirmed to be a non-ossifying fibroma. Conclusion: This case highlights that imaging features of bone lesions on positron emission tomography scans should be correlated with findings of conventional imaging modalities to improve diagnostic
accuracy and prevent unnecessary invasive procedures in oncology patients.
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References
1. Jünger ST, Timmermann B, Pietsch T. Pediatric ependymoma: an overview of a complex disease. Childs Nerv Syst. 2021;37(8):2451-2463. https://doi.org/10.1007/s00381-021-05207-7
2. Kumar P, Rastogi N, Jain M, et al. Extraneural metastases in anaplastic ependymoma. J Cancer Res Ther. 2007;3(2):102-104. https://doi.org/10.4103/0973-1482.34689
3. Alzahrani A, Alassiri A, Kashgari A, et al. Extraneural metastasis of an ependymoma: a rare occurrence. Neuroradiol J. 2014;27(2):175-178. https://doi.org/10.15274/nrj-2014-10017
4. Varan A, Sari N, Akalan N, et al. Extraneural metastasis in intracranial tumors in children: the experience of a single center. J Neurooncol. 2006;79(2):187-190. https://doi.org/10.1007/s11060-006-9123-3
5. Hussain M, Mallucci C, Abernethy L, et al. Anaplastic ependymoma with sclerotic bone metastases. Pediatr Blood Cancer. 2010;55(6):1204-1206. https://doi.org/10.1002/pbc.22604
6. Rousseau P, Habrand JL, Sarrazin D, et al. Treatment of intracranial ependymomas of children: a review of a 15-year experience. Int J Radiat Oncol Biol Phys. 1994; 28(2):381-386. https://doi.org/10.1016/0360-3016(94)90061-2
7. Itoh J, Usui K, Itoh M, et al. Extracranial metastases of malignant ependymoma—a case report. Neurol Med Chir (Tokyo). 1990;30(5):339-345. https://doi.org/10.2176/nmc.30.339
8. Duffner PK, Cohen ME. Extraneural metastases in childhood brain tumors. Ann Neurol. 1981;10(3):261-265. https://doi.org/10.1002/ana.410100311
9. Bowers LM, Cohen DM, Bhattacharyya I, et al. The non-ossifying fibroma: a case report and review of the literature. Head Neck Pathol. 2013;7(2):203-210. https://doi.org/10.1007/s12105-012-0399-7
10. Aoki J, Watanabe H, Shinozaki T, et al. FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology. 2001;219(3):774-777. https://doi.org/10.1148/radiology.219.3.r01ma08774
11. Goodin GS, Shulkin BL, Kaufman RA, et al. PET/CT characterization of fibro-osseous defects in children: 18F-FDG uptake can mimic metastatic disease. AJR Am J Roentgenol. 2006;187(4):1124-1128. https://doi.org/10.2214/ajr.06.0171
12. Mester U, Even-Sapir E. Increased (18)F-fluorodeoxyglucose uptake in benign, nonphysiologic lesions found on whole-body positron emission tomography/computed tomography (PET/CT): accumulated data from four years of experience with PET/CT. Semin Nucl Med. 2007;37(3):206-222. https://doi.org/10.1053/j.semnuclmed.2007.01.001
13. Almuhaideb A, Papathanasiou N, Bomanji J. 18F-FDG PET/CT imaging in oncology. Ann Saudi Med. 2011;31(1):3-13. https://doi.org/10.4103/0256-4947.75771
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