Central Asian Journal of Medical Sciences https://mongoliajol.info/index.php/CAJMS <p><em>The Central Asian Journal of Medical Sciences (CAJMS)</em> is an official English publication of the Mongolian National University of Medical Sciences. CAJMS aims to advance knowledge in medicine, dentistry, public health, nursing, pharmacy and traditional medicine. CAJMS also aims to promote contact between basic and clinical medicine and dentistry. CAJMS is an international journal and has a special focus on research conducted in Central Asian countries including Afghanistan, China, Kazakhstan, Kyrgyzstan, Mongolia, Russia, Tajikistan, Turkmenistan, and Uzbekistan.<br /><br />However, CAJMS welcomes contributors and readers from all countries. Only articles of high quality which present research that makes significant and original contributions are selected for publication. CAJMS includes Editorials, Review Articles, Original Articles, Brief Communications, Case Reports, and Book Reviews.</p> <p><strong>Abstracting and indexing in <a title="Google Scholar" href="https://scholar.google.com" target="_blank" rel="noopener">Google Scholar</a>, <a title="CAJMS" href="https://app.dimensions.ai/discover/publication?and_facet_source_title=jour.1358335" target="_blank" rel="noopener">Dimensions</a> and <a title="CAJMS" href="https://doaj.org/toc/2414-9772" target="_blank" rel="noopener">DOAJ</a>,</strong></p> en-US cybermon@gmail.com (Damdindorj Boldbaatar) gantulga@mas.ac.mn (Gantulga Lkhagva) Wed, 20 Dec 2023 00:00:00 +0000 OJS http://blogs.law.harvard.edu/tech/rss 60 The Effect of Botulinum Toxin- A injection for the Lower Limb in Children with Spastic Cerebral Palsy https://mongoliajol.info/index.php/CAJMS/article/view/3346 <p><strong>Objectives:</strong> To investigate the effect of botulinum toxin-A (BoNT-A) on the age groups and gross motor function classification level in children with cerebral palsy (CP).<br><strong>Method:</strong> In this study, 116 children with spastic CP were investigated. BoNT-A was injected into the spastic muscles of the lower limbs of all participants. All participants received physiotherapy and functional electrical stimulation for 3 months after injection. We measured the change in spasticity using the Modified Ashworth Scale and gross motor function using the GMFM-88. Spasticity was measured before injection and at 1 and 3 months after injection. Measurement of gross motor function was performed before and after the injections. <br><strong>Results:</strong> The effect of BoNT-A injection in combination with physiotherapy and electrical stimulation significantly improved spasticity and gross motor function. After BoNT-A injection, younger children showed reduced spasticity and improved gross motor skills compared to older children. At the gross motor level, sitting, standing, and walking improved in children with gross motor function classification levels I-III, and posture and mobility improved in children with gross motor function classification levels IV-V.<br><strong>Conclusions:</strong> We conclude that BoNT-A injection is effective for improving gross motor function in patients younger than 72 months of age.</p> Narantsetseg Tsegmid, Galindev Batbold, Nasantogtokh Erdenebileg, Batchimeg Shirmen, Davaasuren Ganbold, Gerelmaa Zagd, Baljinnyam Avirmed Copyright (c) 2023 Mongolian National University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0 https://mongoliajol.info/index.php/CAJMS/article/view/3346 Sat, 16 Dec 2023 00:00:00 +0000 Characteristics and Percentage of 30 Days All Cause Hospital Readmissions in Mongolia https://mongoliajol.info/index.php/CAJMS/article/view/3347 <p><strong>Objective</strong>: This study aimed to estimate the 30 days readmissions and predictors of readmission at selected referral hospitals in Mongolia. <br><strong>Methods:</strong> We studied the electronic medical recording database of patients admitted to The State First Central Hospital of Mongolia, The State Second Central Hospital of Mongolia, and The State Third Central Hospital of Mongolia, from January 01, 2023, to June 30, 2023. The Institute for Healthcare Improvement’s Whole system measures white paper adopted the measurement methods for hospital readmission percentages. A descriptive analysis was conducted to calculate the percentage of hospital readmissions. We examined principal diagnoses, length of stay and age and gender are variables. <br><strong>Results</strong>: 31,675 hospital discharged data were recorded in hospitals over the 6-month study period. The average readmission percentage across the three hospitals were 1988 (6.3%). Most of the principal diagnosis leading to readmissions were cancer and chronic diseases.<br><strong>Conclusion:</strong> The highest hospital readmission rates were observed in patients with cancer and chronic diseases, particularly among individuals aged 46-64 years in the referral hospitals.</p> Lkhagvasuren Baasandorj, Ankhbayar Altankhuyag, Enkh-Erdene Erdenesaikhan, Myagmarsuren Shagdarsuren, Garamgai Batdelger, Sarnai Tsagaankhuu, Battur Lkhagvaa, Khurelbaatar Nyamdavaa Copyright (c) 2023 Mongolian National University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0 https://mongoliajol.info/index.php/CAJMS/article/view/3347 Sun, 17 Dec 2023 00:00:00 +0000 Expression of Notch1 in Ameloblastoma and Correlation with CBCT Imaging Subtypes https://mongoliajol.info/index.php/CAJMS/article/view/3348 <p><strong>Objective</strong>: Ameloblastoma (AM) is a prevalent benign odontogenic tumor affecting the jaw bone. Its potential for recurrence and malignant transformation is closely associated with the regulation of signaling pathways. The objective of this study was to examine the expression and clinical significance of Notch1 in AM, along with exploring the correlation between Notch1 expression and AM imaging patterns. <br><strong>Methods</strong>: The streptavidin-peroxidase (S-P) immunohistochemical technique was employed to detect the expression of Notch1 protein in the oral mucosa of 70 AM patients and 25 normal controls. Additionally, the preoperative cone-beam computed tomography (CBCT) images of the patients were classified, and the results were analyzed in relation to the expression of Notch1 protein in AM. <br><strong>Results:</strong> The positive expression rate of Notch1 in the 70 AM patients was 74.29% (52/70), while the Notch1 expression rate in 26 oral mucosa patients was 19.23% (5/26), indicating a statistically significant difference (P &lt; 0.05). The expression rate of Notch1 was 58.06% in single-room AM and lower in multi-room AM (85.29%) and honeycomb AM (100%) (P &lt; 0.01). However, there was no significant difference in the expression rate of Notch1 between multi-room AM and honeycomb AM (P &gt; 0.05). <br><strong>Conclusion:</strong> Notch1 may serve as an important diagnostic indicator in AM, and the apoptosis inhibition ability and cell proliferation ability of single-room AM are lower compared to those of the room and honeycomb types</p> Baoyinbatu Gabiyatu, Wenchao Li, Wurihan, Yuan Tian, Lkhagvasuren Baasandorj, Senhao Li, Sarnai Tsagaankhuu, Damdindorj Boldbaatar Copyright (c) 2023 Mongolian National University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0 https://mongoliajol.info/index.php/CAJMS/article/view/3348 Sat, 25 Nov 2023 00:00:00 +0000 The Biochemical and Hematological Patterns of Hospitalized COVID-19 Patients in Mongolia https://mongoliajol.info/index.php/CAJMS/article/view/3349 <p><strong>Objectives:</strong> The impact of COVID-19 prompted a race to find a treatment that would reduce its mortality. This study aimed to analyze how the clinical and laboratory characteristics reflect the disease process and progression of COVID-19 cases in hospitalized patients of Mongolia, which could be informative in managing patients with COVID-19. <br><strong>Methods:</strong> A cross-sectional study was conducted on the prescription patterns of drugs given to hospitalized patients diagnosed with COVID-19. A total of 1012 participants were recruited in the study. These were identified from the reported positive cases by polymerase chain reaction or antigen reactivity performed in Ulaanbaatar. <br><strong>Result</strong>: A total of 1096 patients participated in this study. The mean age was 51.86 ± 16.98 for male patients and 52.23 ± 16.4 for female patients. It has been revealed that there are statistically significant differences between male and female patients. RBC was 4.56 ± 0.79 M/ UL and 5.08 ± 1.36 M/UL, men and women respectively. The levels of C-reactive protein (CRP) in female COVID-19 patients were significantly higher (46.75 ± 72.83 mg/dL) compared to male patients (33.94 ± 47.96 mg/dL). The platelet count (PLT) was 245.32 ± 77.71 for male patients, while there was a significant reduction in PLT count in female patients (229.30 ± 71.59). <br><strong>Conclusions:</strong> Patients with COVID-19 in Mongolia appeared to remain in the hospital for 6.86 ± 2.43 days, shorter than in other countries. Hematological analysis showed that female patients had elevated C-reactive protein levels and decreased PLT count.</p> Narangarav Nyamdag, Munkhbat Sukhee, Erdenetuya Myagmarsuren, Bayasgalan Gombojav Copyright (c) 2023 Mongolian National University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0 https://mongoliajol.info/index.php/CAJMS/article/view/3349 Mon, 06 Nov 2023 00:00:00 +0000 Introduction to Basics of Pharmacology and Toxicology https://mongoliajol.info/index.php/CAJMS/article/view/3351 <p>No abstract in English</p> Narantungalag Dorjsuren, Sarnai Sukhbaatar Copyright (c) 2023 Mongolian National University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0 https://mongoliajol.info/index.php/CAJMS/article/view/3351 Sun, 17 Dec 2023 00:00:00 +0000 Is Primary Aldosteronism a Hidden Cause of Resistant Hypertension in Mongolia? https://mongoliajol.info/index.php/CAJMS/article/view/3345 <p>No abstract in English</p> Tungalagtamir Shagjaa, Oyuntugs Byambasukh, Damdindorj Boldbaatar Copyright (c) 2023 Mongolian National University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0 https://mongoliajol.info/index.php/CAJMS/article/view/3345 Sat, 16 Dec 2023 00:00:00 +0000 Dehydrocostus Lactone Down - regulates Lipopolysaccharide-induced SAA3 gene activation in the Microglia. https://mongoliajol.info/index.php/CAJMS/article/view/3350 <p><strong>Running Title</strong>: DDL inhibits the LPS-induced SAA3 gene expression in microglia<br><strong>Objective:</strong> Research on the mechanism of Dehydrocostus lactone (DDL) in microglial cells of the brain needs to be improved, despite its reported anti-inflammatory, anticancer, and anti-proliferation properties as a natural product of Eerdun Wurile The precise functions of the Serum amyloid A (SAA) genes are not yet defined. However, these genes are suggested to possess antibacterial properties and can attract monocytes and neutrophils. On the other hand, SAA genes can also induce inflammatory cytokines and metalloproteinases in smooth muscle cells and macrophages, thus promoting inflammation. This study aimed to investigate the impact of DDL on SAA3 gene expression in microglial cells stimulated by LPS.<br><strong>Methods:</strong> The anti-inflammatory effects of DDL were studied using LPS-stimulated murine BV2 microglia. BV2 was cultured in DMEM, and then 4µM DDL was added. Then BV2 was treated with one ng/ml LPS for 24 hours to stimulate. <br><strong>Results</strong>: LPS treatment increased the expression of SAA3 mRNA in BV2 microglial cells, while DDL pre-treatment inhibited LPS-induced SAA3 mRNA expression.<br><strong>Conclusion</strong>: Microglia cells treated with LPS display a significant reduction in the expression of SAA3 gene transcripts upon treatment with DDL.</p> Zhao Fuquan, Seesregdorj Surenjid, Bilegtsaikhan Tsolmon, Oyunchimeg Erdenee, Tsevelmaa Nanjidsuren, Uurtuya Shuumarjav, Shiirevnyamba Avirmed Copyright (c) 2023 Mongolian National University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0 https://mongoliajol.info/index.php/CAJMS/article/view/3350 Sat, 16 Dec 2023 00:00:00 +0000