Preliminary Study Results of Native Mongolian Inonotus Obliquus Extracts in Alloxan-Induced Diabetic Rats

Authors

  • Nyamsurendejid Delgersaikhan Department of Anatomy, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Erdenezaya Odkhuu Department of Anatomy, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Ulzii-Orshikh Namkhai Clinico-Pathological Laboratory, The First Central Hospital of Mongolia, Ulaanbaatar, Mongolia
  • Galindev Batnasan Department of Sciences and Technology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Enkhbaatar Samdan Department of Anatomy, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Enebish Sundui Department of Anatomy, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Amgalanbaatar Dorjkhuu Department of Anatomy, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Dolgorsuren Aldartsogt Department of Anatomy, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Avirmed Amgalanbaatar Department of Anatomy, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

DOI:

https://doi.org/10.24079/cajms.2020.12.007

Keywords:

Inonotus obliquus, Diabetes, Alloxan, Langerhans Islet, Traditional Medicine

Abstract

Objectives: We aimed to investigate the morphological changes and clinical chemistry panel of alloxan-induced diabetic rats for the treatment groups of ethanol or aqueous extracts of Mongolian natural Inonotus obliquus. Methods: Wistar albino rats (n = 80) were randomly assigned into four groups: 1. Healthy control group, 2. Untreated diabetic group, 3. Diabetic group treated with Inonotus obliquus (500 mg/kg per day) water extract, 4. Diabetic group with Inonotus obliquus (500 mg/kg per day) ethanol extract. Diabetes was induced by alloxan 150 mg/kg (single intraperitoneal injection) in the diabetic groups. Results: Both water and ethanol extract of Inonotus obliquus reduced the blood glucose level of diabetes at 48 h after treatment. Histologic and morphology examinations showed that water extracts of Inonotus obliquus alleviated the damage to pancreas tissues in alloxan diabetic rats. Conclusions: We postulate that simple ethanol and water extracts of natural Mongolian Inonotus obliquus have an antihyperglycemic effect that enhances islet cell function in alloxan-induced diabetic rats. The extracts of Mongolian natural Inonotus obliquus are easily producible at low cost and should be further explored as a treatment for diabetes.

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Published

2020-12-29

How to Cite

Delgersaikhan, N., Odkhuu, E., Namkhai, U.-O., Batnasan, G., Samdan, E., Sundui, E., Dorjkhuu, A., Aldartsogt, D., & Amgalanbaatar, A. (2020). Preliminary Study Results of Native Mongolian Inonotus Obliquus Extracts in Alloxan-Induced Diabetic Rats. Central Asian Journal of Medical Sciences, 6(4), 255–261. https://doi.org/10.24079/cajms.2020.12.007

Issue

Vol. 6 No. 4 (2020)

Section

Brief Communications

License

Copyright (c) 2020 Mongolian National University of Medical Sciences

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.