МОНГОЛ ОРНЫ ЗАРИМ ЗҮЙЛ ЭМИЙН УРГАМЛЫН АНТИОКСИДАНТ ИДЭВХ
DOI:
https://doi.org/10.5564/pmas.v0i1.58Keywords:
medicinal plants, antioxidentsAbstract
Сүүлийн жилүүдэд нийлэг аргаар гарган авсан хүнс болон эмийн бүтээгдэхүүнээс татгалзаж, аль болох байгалийн гаралтай бүтээгдэхүүн хэрэглэх хандлага єсєн нэмэгдэж байгаагийн зэрэгцээ эмийн ургамлын антиоксидант идэвхийн судалгаа ихээхэн сонирхол татсан сэдвийн нэг болоод байна.
Бидний судалгааны үр дүнд Монголын ургамлын аймгийн Нийлмэл цэцэгтэн ба Сарнайн овгийн 23 зүйл ургамлын метанолын 51 ханднаас 20 зүйл ургамлын 28 ханд нь чєлєєт радикалыг дарангуйлах сайн идэвхтэй байсан ба ялангуяа ургамлын газрын дээд хэсэг цэцэг, навч, үрийн ханд илүү сайн идэвхтэй байв.
Судалгааны дүнд Chamaerhodos erecta-н газрын дээд хэсэг 100µg/ ml концентрацдаа 81.33±0.96 %, Cotoneaster melanocarpa-н иш 100µg/ml концентрацдаа 92.14±0.98 %, Dasiphora fruticosa-н навч, цэцэг, иш 25µg/ml концентрацдаа тус бүр 49.61±4.4 %, 49.98±2.87 %, 57.7±0.84 %, Dasiphora parvifolia-н навч, цэцэг 25µg/ml концентрацдаа 43.22±1.4 %, Filipendula palmatа- н навч, үр 50µg/ml концентрацдаа тус бүр 56.4±0.75 %, 55.41±2.1 %, Rubus sachalinensis-н навч 50µg/ml концентрацдаа 65.22±0.91%-аар чєлєєт радикалыг дарангуйлах онцгой сайн идэвхтэй үр дүнтэй байлаа.
Түлхүүр үг: Нийлмэл цэцэгтэн, Сарнайн овог, антиоксидант идэвх, DPPH радикал
Screening of Mongolian Medicinal Plants for their Antioxidant Activity
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are implicated in a wide range of human diseases such as atherosclerosis, certain cancer, inflammation, diabetes, liver injury, Alzheimer, Parkinson and coronary heart pathologies [1, 11]. When an imbalance between ROS/RNS generation and antioxidants occurs, oxidative damage will spread over all the cell targets (DNA, lipids, proteins).
Antioxidants in foods and medicinal plants have attracted interest in recent years.
The aim of the present study was to search the antioxidant active compounds or a new plant species through the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging method of the methanol extracts from 23 plant species belonging to 2 botanical families (Compositae, Rosaceae) collected from natural reserves. The antioxidant activity of these plant extracts were compared with standard solution of rutin.
From the 51 plant extracts studied, twenty eight gave IC50 values lower than 200µg/ml. The strongest IC50 values were given by the methanol extracts of Chamaerhodos erecta (aerial parts), Dasiphora parvifolia (leaves, flowers), Cotoneaster melanocarpa (stems), Rubus sachalinensis (stems, leaves), Dasiphora fruticosa (flowers, leaves, stems), Cotoneaster melanocarpa (stems), Filipendula palmata (seeds, leaves), Rubus sachalinensis(leaves).
Therefore, these plants may have great relevance in the prevention and therapies of diseases in which free radicals are implicated. In further, more detailed studies on the chemical composition of those extracts as well as studies with other models such as in vivo assays will be called for an interest.
Acknowledgements We are grateful to prof A.H.Brantner (Laboratory of Pharmacognosy, University of Graz, Austria) for her helpful suggestion. This study was partially supported by Honda foundation, Japan.
DOI: http://dx.doi.org/10.5564/pmas.v0i1.58
Proceedings of the Mongolian Academy of Sciences 2010 No.1 pp.48-56
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