Perspectives on molecular mechanisms of post-translational modification and their functional influence on certain diseases
DOI:
https://doi.org/10.5564/pib.v39i1.3143Keywords:
protein modification, protein-protein interaction, disease, database of PTMsAbstract
Post-translational modification (PTM) is a vital biological process significantly impacting protein structure and function. It involves adding functional groups to the main and side chains during and after protein synthesis, thereby modifying their structure and function. PTMs are essential in shaping proteins into their final, functional, and three-dimensional forms. While numerous PTMs are still under active investigation and exploration. Herewith, we briefly overview some of the most prevalent PTMs, elucidate their associated functions, and establish connections between PTMs and a diverse range of diseases. Notably, we elucidate the profound influence of PTMs on neurodegenerative diseases and cancer, and provide a deep understanding of their many effects. Lastly, it considers a concise overview of PTM computational methods and databases, shedding light on the cutting-edge techniques and resources used to analyze and explore post-translational modifications.
Трансляцийн дараах өөрчлөлтийн молекул механизм ба түүний зарим өвчлөлд үзүүлэх нөлөө
Хураангуй. Трансляцийн дараах өөрчлөлт (ТДӨ) нь уургийн нийлэгжлийн үед, эсвэл нийлэгжлийн дараа уургийн гол болон хажуугийн гинжинд функциональ бүлэг нэмэх замаар уургийн бүтэц болон үйл ажиллагаанд нөлөөлдөг биологийн чухал үйл ажиллагааны нэг юм. Маш олон тооны ТДӨ-үүд судлагдсаар байгаа бөгөөд энэхүү тойм өгүүлэлд бид хамгийн түгээмэл арван ТДӨ-үүд болон тэдгээрийн үйл ажиллагааны талаар авч үзэв. Үүнээс гадна ТДӨ нь төрөл бүрийн өвчин, эмгэгтэй холбоотой байдгаас түгээмэл тохиолддог тархи, мэдрэлийн эмгэгүүд болон хавдрын биологийн үйл ажиллагаанд ТДӨ хэрхэн нөлөөлж байгаа талаар, түүнчлэн ТДӨ-ийн судалгааны аргууд болон мэдээллийн сангийн тухай тоймлон танилцуулав.
Түлхүүр үгс: уургийн өөрчлөлт, уураг-уургийн харилцан үйлчлэл, ТДӨ-ийн мэдээллийн сан
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