TY - JOUR AU - Damdindorj, Mungunnaran AU - Borjihan, Gereltu AU - Gendaram, Odontuya AU - Bold, Bayarmaa PY - 2021/12/29 Y2 - 2024/03/28 TI - Synthesis and antihyperlipidaemic activity of a new piperine derivative JF - Mongolian Journal of Chemistry JA - Mong. J. Chem. VL - 22 IS - 48 SE - Articles DO - 10.5564/mjc.v22i48.1782 UR - https://mongoliajol.info/index.php/MJC/article/view/1782 SP - 13-18 AB - <p>Long pepper (<em>Piper longum </em>Linn.) is widely used as a medicinal substance in traditional Ayurvedic medicine. Its major alkaloid piperine is the main active constituent with various therapeutic activities and has low solubility in water. In this study, a soluble new derivative of a piperine alkaloid, named N-leucinylpiperamide was synthesized. The animal experiment showed that N-leucinylpiperamide has more hypolipidemic effects than commercially available simvastatin and piperine in modulating serum lipids in Wistar male rats. At the amount of 10 mg/kg bw, it significantly reduced TC (-52.4%), TG (-61.7%), and LDL-C (-27.8%), respectively, and increased HDL-C (+147.4%) in the serum of the high-lipid model group. Furthermore, the synthesized N-leucinylpiperamide had no noticeable cytotoxicity against HepG2 cell line <em>in vitro</em>. Thus, our study shows that N-leucinylpiperamide has an ability to improve serum lipid profile in hyperlipidemic model rats and could be a valuable promising agent for the preventing hyperlipidemia.</p> ER -