Pharmacological insights into Ipomoea staphylina: Therapeutic activities and the isolated bioactive metabolic compounds

Authors

DOI:

https://doi.org/10.5564/mjc.v25i52.3195

Keywords:

Ipomoea staphylina, Biological activities, Plant extract, Isolation

Abstract

This review comprehensively explores I. staphylina's traditional uses, diverse applications, and pharmacological activities. Extensively used in traditional medicine, this plant addresses a range of ailments, including stomach disorders, respiratory issues, and rheumatism. Research has highlighted its significant antimicrobial, anti-inflammatory, antioxidant, antidiabetic, anthelmintic, and analgesic properties. Notably, its antiulcer activity highlights its potential as a novel antiulcer agent, while hepatoprotective and nephroprotective effects suggest therapeutic applications in liver and kidney disorders. Studies on its anti-diabetic potential show significant reductions in blood glucose levels and positive impacts on biochemical markers. The plant's anti-mutagenic activity against base-pair mutations expands its potential applications. The review also discusses the isolation and pharmacological applications of pure compounds identified through LC-MS and NMR analyses. This review identifies I. staphylina as a promising source of bioactive compounds with therapeutic potential, emphasizing the need for further research to isolate and characterize its active constituents.

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Author Biography

Suseem SR, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India

Assistant Professor (Sr)

References

Dias D.A., Urban S., Roessner U. (2012). A historical overview of natural products in drug discovery. Metabolites, 2(2), 303-336. https://doi.org/10.3390/metabo2020303

Dar R.A., Shahnawaz M., Rasoo, S., Qazi P.H. (2017). Natural product medicines: A literature update. J. Phytopharmacol., 6(6), 349-351.

https://doi.org/10.31254/phyto.2017.6608

Capasso R., Izzo A.A., Pinto L., Bifulco T., Vitobello C., et al., (2000). Phytotherapy and quality of herbal medicines. Fitoterapia, 71, S58-S65. https://doi.org/10.1016/S0367-326X(00)00173-8

Calixto J.B. (2000). Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Braz. J. Med. Biol. Res., 33, 179-189. https://doi.org/10.1590/S0100-879X2000000200004

Rizvi S.I., Mishra N. (2013) Traditional Indian medicines used for the management of diabetes mellitus. J. Diabetes Res., 2013(1). https://doi.org/10.1155/2013/712092

Harvey A.L. (2008). Natural products in drug discovery. Drug Discov. Today, 13(19-20), 894-901. https://doi.org/10.1016/j.drudis.2008.07.004

Atanasov A.G., Zotchev S.B., Dirsch V.M., Supuran C.T. (2021). Natural products in drug discovery: Advances and opportunities. Nat. Rev. Drug Discov., 20(3), 200-216. https://doi.org/10.1038/s41573-020-00114-z

Balandrin M.F., Kinghorn A.D., Farnsworth N.R. (1993) Plant-derived natural products in drug discovery and development. In: Human Medicinal Agents from Plants. ACS Pubs., 534, 2-12. https://doi.org/10.1021/bk-1993-0534.ch001

Ulrich-Merzenich G., Panek D., Zeitler H., Vetter H., Wagner H. (2010) Drug development from natural products: Exploiting synergistic effects. Indian J. Exp. Biol., 48(3), 208-219.

Muralidharan R., Narasimhan D. (2013) Plants used for topical application from Gingee hills, Tamil Nadu, India. Current Botany, 3(4), 49-52.

Sarvalingam A., Rajendran A., Sivalingam R. (2014) Wild edible plant resources used by the Irulas of the Maruthamalai Hills, Southern Western Ghats, Coimbatore, Tamil Nadu. Indian J. Nat. Prod. Resour., 5(2), 198-201.

Staples G.W. (1996) The identity of Ipomoea staphylina (Convolvulaceae) in Asia. Taiwania, 41(3), 185-196. https://doi.org/10.6165/tai.1996.41.185

Narra P., Kandavara P. (2014) Evaluation of cytotoxic, antimicrobial, and anti-inflammatory properties from the latex of Ipomea staphylina. J. Microbiol. Biotech. Food Sci., 3(5), 350-352. https://office2.jmbfs.org/index.php/JMBFS/article/view/6993.

Reddy D.P., Kota R., Anarthe S.J., Raghavendra M. (2013) Isolation, characterization of phytoconstituents and pharmacological screening of Ipomoea staphylina. Asian J. Pharm. Clin. Res., 6(1), 30-33.

Firdous S.M., Koneri R. (2012) In vivo and in vitro antiinflammatory activity of leaves of Ipomoea staphylina. Int. J. Pharm. Pharm. Sci., 4(5) 339-343.

Kottaimuthu R. (2008) Ethnobotany of the Valaiyans of Karandamalai, Dindigul District, Tamil Nadu, India. Ethnobototanical Leaflets 1, 195-203.

Available at: https://opensiuc.lib.siu.edu/ebl/vol2008/iss1/24

Kumar T.D., Pullaiah T. (1999) Ethno-Medico-Botany of Chenchus of Mahaboobnagar District, Andhra Pradesh. Anc. Sci. Life, 19(1-2), 31.

Shobana P. Devi. Begum, M. Shabana, (2020) Antioxidant and antiperoxidative effects of Ipomoea staphylina in Streptozotocin-induced diabetic rats. Res. J. Agril. Sci., 12(1), 374-379.

Firdous S.M., Koneri R. (2014) Antidiabetic and antioxidant activities of Ipomoea staphylina Leaves in Streptozotocin (STZ) induced diabetic mice. J. PharmaSciTech, 3(2). http://www.pharmascitech.in

Firdous S.M., Singh A. (2016) Effect of Ipomoea staphylina leaves on streptozotocin-nicotinamide induced type-II diabetes in Wistar rats. Asian Pac. J. Health Sci., 3, 30-44. https://doi.org/10.21276/apjhs.2016.3.3.6

Ghosh S., Firdous S.M. (2014) Effect of aqueous extract of Ipomoea staphylina on Indian earthworm. Evaluation, 12, 13.

Banerjee A., Firdous S.M. (2015) Antiulcer activity of hydroalcoholic extract of Ipomoea staphylina plant in rats. Bangladesh J. Pharmacol., 10(3), 652-653. https://doi.org/10.3329/bjp.v10i3.24034.

Bag A.K., Mumtaz S.F. (2013) Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves. Bangladesh J. Pharmacol., 8(3), 263-268. https://doi.org/10.3329/bjp.v8i3.14845.

Jeyadevi R., Ananth D.A., Sivasudha T. (2019) Hepatoprotective and antioxidant activity of Ipomoea staphylina Linn. Clin. Phytosci., 5(1), 1-11.

https://doi.org/10.1186/s40816-019-0112-4

Ghosh S., Firdous S.M. (2014) Evaluation of analgesic activity of hydroalcoholic extract of Ipomoea staphylina. TJPS, 38(2), 57-60. https://doi.org/10.56808/3027-7922.1971

Santhoshkumar T., Rahuman A.A., Bagavan A., Kirthi A.V., Marimuthu S., et al. (2012) Efficacy of adulticidal and larvicidal properties of botanical extracts against Haemaphysalis bispinosa, Hippobosca maculata, and Anopheles subpictus. Parasitol. Res., 111, 1833-1840. https://doi.org/10.1007/s00436-011-2608-9

Banerjee A., Firdous S.M. (2020) In vitro antimutagenic activity of Ipomoea staphylina. Bangladesh J. Pharmacol., 15(1), 41-43.

https://doi.org/10.3329/bjp.v15i1.43446

Villaseñor I.M., Angelada J., Canlas A.P., Echegoyen D. (2002) Bioactivity studies on β‐sitosterol and its glucoside. Phytother. Res., 16(5), 417-421.

https://doi.org/10.1002/ptr.910

Rashed K. (2020) Beta-sitosterol medicinal properties: a review. J. Sci. Innov. Technol., 9, 208-212. 226313318

Ambavade S.D., Misar A.V., Ambavade P.D. (2014) Pharmacological, nutritional, and analytical aspects of β-sitosterol: a review. Orient. Pharm. Exp. Med., 14, 193-211. https://doi.org/10.1007/s13596-014-0151-9

Prakash D., Gupta C., Sharma G. (2012) Importance of phytochemicals in nutraceuticals. J. Chin. Med. Res. Dev., 1(3), 70-78.

Nwozo O.S., Effiong E.M., Aja P.M., Awuchi C.G. (2023) Antioxidant, phytochemical, and therapeutic properties of medicinal plants: A review. Int. J. Food Prop., 26(1), 359-388. https://doi.org/10.1080/10942912.2022.2157425

Luo B., Wen Y., Ye F., Wu Y., Li N., et al., (2023) Bioactive phytochemicals and their potential roles in modulating gut microbiota. J. Agric. Food Res., 12, 100583. https://doi.org/10.1016/j.jafr.2023.100583

Kawatra A., Gupta S., Dhankha, R., Singh P., Gulati P. (2023) Application of phytochemicals in therapeutic, food, flavor, and cosmetic industries. In: Swamy M.K., Kumar A. (eds) Phytochemical Genomics. Springer, Singapore, 85-108. https://doi.org/10.1007/978-981-19-5779-6_4

Luo Y., Zeng Y., Peng J., Zhang K., Wang L., et al., (2023) Phytochemicals for the treatment of metabolic diseases: Evidence from clinical studies. Biomed. Pharmacother, 165, 115274. https://doi.org/10.1016/j.biopha.2023.115274

Padmashree M.S., Ashwathanarayana R., Raja Naika R.B. (2018) Antioxidant, cytotoxic and nutritive properties of Ipomoea staphylina Roem & Schult. plant extracts with preliminary phytochemical and GC-MS analysis. A. J. Pharm. Parmacol., 4(4), 473-92. https://doi.org/10.31024/ajpp.2018.4.4.16

Tucker J.M., Townsend D.M. (2005) Alpha-tocopherol: Roles in prevention and therapy of human disease. Biomed. Pharmacother., 59(7), 380-387.

https://doi.org/10.1016/j.biopha.2005.06.005

Rendle P.M., Kassibawi F., Johnston K.A., Hart J.B., Cameron S.A., et al., (2016) Synthesis and biological activities of d-chiro-inositol analogues with insulin-like actions. Eur. J. Med. Chem., 122, 442-451.

https://doi.org/10.1016/j.ejmech.2016.06.047

Xiong R., Sauvage F., Fraire J.C., Huang C., De Smed S.C., et al., (2023) Photothermal nanomaterial-mediated photoporation. Acc. Chem. Res., 56(6), 631-643.

https://doi.org/10.1021/acs.accounts.2c00770

Zhang L., Gu F.X., Chan J.M., Wang A.Z., Langer R.S., et al., (2007) Nanoparticles in medicine: Therapeutic applications and developments. Clin. Pharmacol. Ther., 83(5), 761-769. https://doi.org/10.1038/sj.clpt.6100400

Yildiz I., Shukla S., Steinmetz N.F. (2011) Applications of viral nanoparticles in medicine. Curr. Opinion Biotech., 22(6), 901-908.

https://doi.org/10.1016/j.copbio.2011.04.020

Van Rijt S.H., Bein T., Meiners S. (2014) Medical nanoparticles for next generation drug delivery to the lungs. Eur. Respir. J., 44(3), 765-774.

https://doi.org/10.1183/09031936.00212813

Pugazhendhi S. (2020) Synthesis of Ipomoea staphylina plant extract mediated silver nanoparticles. Materials Today: Proceedings, 33, 4626-4629.

https://doi.org/10.1016/j.matpr.2020.08.287

Narayanan L., Suseem S.R., Kamara C. (2024) An investigation into the larvicidal activity of biologically synthesized silver and copper oxide nanoparticles against Mosquito larvae. Chemistry and Biodiversity 21(4), e202301774. https://doi.org/10.1002/cbdv.202301774

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Published

2024-09-11

How to Cite

Narayanan, L., & SR, S. (2024). Pharmacological insights into Ipomoea staphylina: Therapeutic activities and the isolated bioactive metabolic compounds. Mongolian Journal of Chemistry, 25(52). https://doi.org/10.5564/mjc.v25i52.3195

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Review