Phytochemical investigation and in vitro anthelmintic evaluation of extracts of Wild Cinchona (Neolamarckia cadamba Roxb.) fruits
DOI:
https://doi.org/10.5564/mjc.v24i50.2269Keywords:
Neolamarckia cadamba, phytochemical investigation, anthelmintic evaluation, anthelmintic mechanismsAbstract
Neolamarckia cadamba Roxb., a plant commonly used in Indian traditional medicines, has been recognized for its
anthelmintic properties. This study aimed to evaluate the in vitro anthelmintic activity of N. cadamba fruit extracts against
Ascaridia galli (roundworm), Raillietina spiralis (tapeworm), and Pheretima posthuma (Indian adult earthworm). The hydro-methanolic extract of N. cadamba fruits exhibited superior anthelmintic activity compared to the ethyl acetate extract.
Phytochemical analysis of the extracts revealed the presence of phenols, tannins, saponins, glycosides, phytosterols,
flavonoids, and terpenoids. Furthermore, the contents of phenolics, flavonoids, proanthocyanidins, and anthocyanins in the
fruit extracts were quantified. The quantitative analysis of total phenolic content of extracts revealved that hydromethanolic
extract contains higher quantity of phenolics, flavonoids, proanthocyanidins, and anthocyanins in comparision to the
ethylacetate extract. These findings support the observation that hydro-methanolic extract of N. cadamba fruits exhibited
superior anthelmintic activity compared to the ethyl acetate extract because polyphenolic compounds are well established
for their anthelmintic activity.
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