Synthesis and antifungal activity investigation of a novel clotrimazole derivative

Authors

  • B Zoljargal Department of Biochemistry and Laboratory medicine, School of Biomedicine, Health Sciences University of Mongolia, Zorig Street-3, Ulaanbaatar 210648
  • N Davaasuren Department of Medical Chemistry, School of Pharmacy, Health Sciences University of Mongolia

DOI:

https://doi.org/10.5564/mjc.v14i0.194

Keywords:

Clotrimazole, biphenyl derivative, azole antifungals

Abstract

Azole antifungal agents disrupt fungal ergosterol synthesis that is essential for the formation of fungal cell membrane by preventing 14-α-demethylase enzyme from binding to its substrate. Clotrimazole is one of the first generations of azole antifungal agents. To discover a novel azole antifungal agent, biphenyl derivative was synthesised together with clotrimazole by multistep linear synthesis. Structures of synthesised azole agents have been validated by spectral analysis and potential antifungal activity of both compounds was determined on an yeast, E.coli and M.luteus by using a disk diffusion method. Clotrimazole and its biphenyl derivative were active against yeast but a novel compound resulted less activity than clotrimazole. Antibacterial effect was not observed for either azole agents.

DOI: http://dx.doi.org/10.5564/mjc.v14i0.194

Mongolian Journal of Chemistry 14 (40), 2013, p28-32

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Published

2014-10-01

How to Cite

Zoljargal, B., & Davaasuren, N. (2014). Synthesis and antifungal activity investigation of a novel clotrimazole derivative. Mongolian Journal of Chemistry, 14, 28–32. https://doi.org/10.5564/mjc.v14i0.194

Issue

Vol. 14 (2013)

Section

Articles

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