Clinical and laboratory characterization of pyelonephritis and hyperoxaluria in children

Authors

  • Unurjargal Yadmaa Department of Pharmacology and Clinical Pharmacy, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Batkhuyag Purevjav Department of Pharmacology and Clinical Pharmacy, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Ouynbileg Sharavdorj Department of Pharmacology and Clinical Pharmacy, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Lkhagvasuren Tsolmon Department of Pharmacology and Clinical Pharmacy, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Munkhdelger Baasan Department of Pharmacology and Clinical Pharmacy, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Ariunaa Zundui Department of Pharmacognosy and Pharmachemistry, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Maralmaa Lkhagvasuren Department of Biomedicine, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Tserenchunt Ganbold Department of Biomedicine, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Tungalag Dagdanbazar Department of Biomedicine, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Saingerel Mendgerel Department of Biomedicine, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Ider Sarantuya Department of Biomedicine, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
  • Munkhtulga Erdenetsetseg Department of Biomedicine, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia

Keywords:

Children Pyelonephritis, Hyperoxaluria, Malondialdehyde

Abstract

Pyelonephritis (PN) and hyperoxaluria (HO) are significant pediatric renal conditions. Their coexistence often complicates clinical management and exacerbates renal tissue injury through oxidative stress. This study aims to characterize the clinical and laboratory profiles of children with these conditions and evaluate the role of Malondialdehyde (MDA) as a marker of renal damage. This retrospective study analyzed clinical and laboratory data from 48 pediatric patients diagnosed with PN and HO between 1996 and 1997. Patients were categorized into three groups: PN, HO, and combined PN/HO. Clinical syndromes and laboratory markers, including leukocyturia, microhematuria, proteinuria, and MDA levels, were evaluated. Toxic syndrome was the most prevalent clinical manifestation in the combined PN/HO group. Abdominal pain syndrome was significantly more frequent in patients with concurrent PN and HO compared to isolated cases. Laboratory analysis revealed distinct profiles: leukocyturia (74±7.6) was predominant in PN, microhematuria (88±9.6) in HO, and high-grade proteinuria (330±14 mg%) in the combined group. Notably, serum and urine MDA levels were significantly elevated in HO and combined cases, indicating increased oxidative stress. The combined occurrence of PN and HO leads to more severe clinical and laboratory alterations than either condition alone. MDA levels serve as a critical diagnostic indicator for assessing oxalate-induced renal tissue damage.

Abstract
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Published

2026-07-20

Issue

Vol. 7 No. 1 (2026)

Section

Articles

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Copyright (c) 2026 Unurjargal Yadmaa, Batkhuyag Purevjav, Ouynbileg Sharavdorj, Lkhagvasuren Tsolmon, Munkhdelger Baasan, Ariunaa Zundui, Maralmaa Lkhagvasuren, Tserenchunt Ganbold, Tungalag Dagdanbazar, Saingerel Mendgerel, Ider Sarantuya, Munkhtulga Erdenetsetseg

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How to Cite

Yadmaa, U., Purevjav, B., Sharavdorj, O., Tsolmon, L., Baasan, M., Zundui, A., Lkhagvasuren, M., Ganbold, T., Dagdanbazar, T., Mendgerel, S., Sarantuya, I., & Erdenetsetseg, M. (2026). Clinical and laboratory characterization of pyelonephritis and hyperoxaluria in children. Journal of Eastern - Western Pharmacology and Pharmacy, 7(1), 44-47. https://doi.org/10.64269/jewpp.v7i1.5788